
Retrosynthesis and Liquid-Liquid Extraction: Crash Course Organic Chemistry #34
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Date: 2022-04-04
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Comments and reviews: 4
Ben
There-s some slightly strange reasoning here. First of all, you can-t just say that when a starting material and a product both have the same absolute configuration label, you must have overall retention: CIP priority means that you can invert a stereocentre with a lower priority group to get a product with the same R or S label. Then, in the retrosynthesis, there was no real discussion of which bonds to break beyond -we-ll break these bonds because we-ve covered this chemistry. - Even if, as a chemist, you don-t know how to make a particular bond, it is your due diligence to look up the possibility of the alternative disconnection if your route is not especially concise (like the one in the video. Perhaps aldol chemistry hasn-t been covered in this series yet, but it is one of the most classical kinds of C-C disconnection, and would be equally applicable here.
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There-s some slightly strange reasoning here. First of all, you can-t just say that when a starting material and a product both have the same absolute configuration label, you must have overall retention: CIP priority means that you can invert a stereocentre with a lower priority group to get a product with the same R or S label. Then, in the retrosynthesis, there was no real discussion of which bonds to break beyond -we-ll break these bonds because we-ve covered this chemistry. - Even if, as a chemist, you don-t know how to make a particular bond, it is your due diligence to look up the possibility of the alternative disconnection if your route is not especially concise (like the one in the video. Perhaps aldol chemistry hasn-t been covered in this series yet, but it is one of the most classical kinds of C-C disconnection, and would be equally applicable here.
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Hex
Oh, hey! Crash course is doing chemistry now. Maybe it will help me make sense of the college course I barely made it through, and. nope. Already in the fetal position.
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Oh, hey! Crash course is doing chemistry now. Maybe it will help me make sense of the college course I barely made it through, and. nope. Already in the fetal position.
reply
nicholas
This is an amazing video. Orgo is just one of those classes that breaks your soul. I-m happy that I still understood 80% of what the video was teaching.
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This is an amazing video. Orgo is just one of those classes that breaks your soul. I-m happy that I still understood 80% of what the video was teaching.
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4: 20 actually the number of carbon atoms on the starting molecule is 15. i think tou missed the two ethyl groups on the amide group
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4: 20 actually the number of carbon atoms on the starting molecule is 15. i think tou missed the two ethyl groups on the amide group
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