Why 90% Of People Never Get Lean (It's Not Genetics)
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Date: 2025-11-01
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Comments and reviews: 20
MajorGRecording
Serotonin is one of the main neurotransmitters behind the effects mentioned in the video. There are multiple receptors which respond to serotonin, some dealing with digestion and the autonomic nervous system, others with the feeling of depression. This is one of the causes of nervous eating or binge eating, because of how emotions can be connected with hunger. The majority of serotonin production is actually in the gut, not the brain. You mentioned stretch receptors located in the stomach that fire off a serotonin message to the brain giving you the sensation of being full. This also mediates one of my favorite reflexes, called the Gastrocolic reflex. When the stomach becomes full it triggers stretch receptors in the lining, and serotonin messages the colon telling it to make room for the food that is coming down the pipeliine. (That's why you need to poop after a big meal) There is a rare genetic disorder called Prader-Willi which demonstrates a genetic component in the relation of hunger and genetics. In Prader-Wiili, they lack the receptors sites in the brain for giving the feeling satiety, and as a result they want to eat constantly. Perhaps variations on chromosome 15 might be responsible for why some people are fat, and others skinny due to the number of receptor sites for serotonin 5HT. Your advice seems to be on how to manage those serotonin responses. Exercise is also part of a valid treatment in the management of depression due to all the effects on serotonin receptors sites! Exercise gives you a sense of well being due to neurotransmitter receptors being triggered.
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Serotonin is one of the main neurotransmitters behind the effects mentioned in the video. There are multiple receptors which respond to serotonin, some dealing with digestion and the autonomic nervous system, others with the feeling of depression. This is one of the causes of nervous eating or binge eating, because of how emotions can be connected with hunger. The majority of serotonin production is actually in the gut, not the brain. You mentioned stretch receptors located in the stomach that fire off a serotonin message to the brain giving you the sensation of being full. This also mediates one of my favorite reflexes, called the Gastrocolic reflex. When the stomach becomes full it triggers stretch receptors in the lining, and serotonin messages the colon telling it to make room for the food that is coming down the pipeliine. (That's why you need to poop after a big meal) There is a rare genetic disorder called Prader-Willi which demonstrates a genetic component in the relation of hunger and genetics. In Prader-Wiili, they lack the receptors sites in the brain for giving the feeling satiety, and as a result they want to eat constantly. Perhaps variations on chromosome 15 might be responsible for why some people are fat, and others skinny due to the number of receptor sites for serotonin 5HT. Your advice seems to be on how to manage those serotonin responses. Exercise is also part of a valid treatment in the management of depression due to all the effects on serotonin receptors sites! Exercise gives you a sense of well being due to neurotransmitter receptors being triggered.
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ArcadeAndrew.
ehh this is an L video TBH. not only is the editing for B roll stuff like the swaps and veggies WAY TO QUICK, but this isn't at all what happens. Yes the hypothalamus controls that. and pretty much everything else related to body function to maintain homeostasis. the hypothalamus will actually prevent you from overeating and gaining weight as well, which is why things like the sugar crash, rest and digest etc exist. so your body can properly rest and digest food and not overeat. There are MUCH different brain signal pathways that are responsible for overeating that have nothing to do with the hypothalamus.
Second: its shocking that its 2025 and we STILL believe in conservation mode. THIS HAS BEEN DISPROVEN TIME AND TIME AGAIN. there is no such thing as conservation mode. people LOVE to point out to the biggest losers regaining weight right. heres what actually happens: if you weigh 350lbs, that mass you have takes energy to maintain, your BMR is higher naturally. When you loose it your BMR drops. conservation mode confirmed! no, its literally just the body no longer needs to maintain that mass anymore. this is conversely why building muscle is important, so your BMR remains higher.
Sure you touched on some of this stuff, but the whole conservation mode is a disproven myth and the effects are only present in the caase of: Extreme weight loss of fat that isnt accompanied by muscle gain, and no change in consistent dietary habits.
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ehh this is an L video TBH. not only is the editing for B roll stuff like the swaps and veggies WAY TO QUICK, but this isn't at all what happens. Yes the hypothalamus controls that. and pretty much everything else related to body function to maintain homeostasis. the hypothalamus will actually prevent you from overeating and gaining weight as well, which is why things like the sugar crash, rest and digest etc exist. so your body can properly rest and digest food and not overeat. There are MUCH different brain signal pathways that are responsible for overeating that have nothing to do with the hypothalamus.
Second: its shocking that its 2025 and we STILL believe in conservation mode. THIS HAS BEEN DISPROVEN TIME AND TIME AGAIN. there is no such thing as conservation mode. people LOVE to point out to the biggest losers regaining weight right. heres what actually happens: if you weigh 350lbs, that mass you have takes energy to maintain, your BMR is higher naturally. When you loose it your BMR drops. conservation mode confirmed! no, its literally just the body no longer needs to maintain that mass anymore. this is conversely why building muscle is important, so your BMR remains higher.
Sure you touched on some of this stuff, but the whole conservation mode is a disproven myth and the effects are only present in the caase of: Extreme weight loss of fat that isnt accompanied by muscle gain, and no change in consistent dietary habits.
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AhimSaah
This all sounds very cute and logical but calory restriction is way worse than you showed it here. In my case it destroys my sleep completely. After 3-4 weeks of 15% calory restriction my body doesn't want to sleep anymore, either it takes me 3 hours to fall asleep or a wake up 3. 30am with terrible stomach cramps. In order to be able to go back to sleep I need to eat which means I have to skip breakfast when I finally get up. I ended up eating 2 meals a day, 2000 calories 30 minutes before going to be to be able to fall asleep and 1000 calories in the middle of the night to be able to go back to sleep after having woken up. As this is not a sustainable lifestyle I soon quit. So, getting lean for me is not possible. I can't survive without sleep. Stop lying that we can get lean. 99% of the poeple CANNOT get lean ever.
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This all sounds very cute and logical but calory restriction is way worse than you showed it here. In my case it destroys my sleep completely. After 3-4 weeks of 15% calory restriction my body doesn't want to sleep anymore, either it takes me 3 hours to fall asleep or a wake up 3. 30am with terrible stomach cramps. In order to be able to go back to sleep I need to eat which means I have to skip breakfast when I finally get up. I ended up eating 2 meals a day, 2000 calories 30 minutes before going to be to be able to fall asleep and 1000 calories in the middle of the night to be able to go back to sleep after having woken up. As this is not a sustainable lifestyle I soon quit. So, getting lean for me is not possible. I can't survive without sleep. Stop lying that we can get lean. 99% of the poeple CANNOT get lean ever.
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pain. 497
What works for me coming from someone that went from 290 - 186lbs (goal is 170lbs.
I used to eat 3 meals a day and noticed I ate way too much. The solution was to eat 2 giant meals a day with a lil snacks in between.
I eat as much protein as I can get like fish, eggs, chicken, fruits like bananas, and some healthy fats like peanuts with yogurt.
Don't copy me, but I only eat around 1800 cals a day (it works for me) and do resistance training and cardio like pullups, stationary biking, and whatnot for an hour 5 days a week.
I stay away from high sugar and extremely processed junk. The most important of em all is 1 gallon of water a day and my green tea.
Everything I eat and drink is measured via scale in grams to know exactly what I'm consuming.
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What works for me coming from someone that went from 290 - 186lbs (goal is 170lbs.
I used to eat 3 meals a day and noticed I ate way too much. The solution was to eat 2 giant meals a day with a lil snacks in between.
I eat as much protein as I can get like fish, eggs, chicken, fruits like bananas, and some healthy fats like peanuts with yogurt.
Don't copy me, but I only eat around 1800 cals a day (it works for me) and do resistance training and cardio like pullups, stationary biking, and whatnot for an hour 5 days a week.
I stay away from high sugar and extremely processed junk. The most important of em all is 1 gallon of water a day and my green tea.
Everything I eat and drink is measured via scale in grams to know exactly what I'm consuming.
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jaytee9111
I broke my hypothalamus for a while. I did intermittent fastingketo for a month, giving myself a 1 hour eating window every day. After that month, I lost the feeling of hunger. When I stopped intermittent fasting, I would actually forget to eat. Since I didn't have that scheduled eating window every day and I never felt hungry, I would occasionally wake up with a headache and realize I hadn't eaten for two days.
After going from 185lb to 150lbs unintentionally, I realized I needed to start scheduling eating again, making sure to eat 3 meals per day. Eating three meals per day caused me to regain the ability to feel hunger, although it is far more muted than it used to be.
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I broke my hypothalamus for a while. I did intermittent fastingketo for a month, giving myself a 1 hour eating window every day. After that month, I lost the feeling of hunger. When I stopped intermittent fasting, I would actually forget to eat. Since I didn't have that scheduled eating window every day and I never felt hungry, I would occasionally wake up with a headache and realize I hadn't eaten for two days.
After going from 185lb to 150lbs unintentionally, I realized I needed to start scheduling eating again, making sure to eat 3 meals per day. Eating three meals per day caused me to regain the ability to feel hunger, although it is far more muted than it used to be.
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onodera3964
One more important aspect is the shape of your food. Apples might be good for you, but there's a big difference between an apple smoothie, a bag of apple slices and a whole apple, even if they all have the same calories. There more you have to pay attention to eating, the faster your satiety meter rises.
If you can make a great chicken sandwich, it will be even better if you just put everything on a plate and eat it piece by piece: slice off a piece of the grilled chicken breast, dab it into the garlic yoghurt sauce, spear a tomato slice, scoop a bit of shredded lettuce, take a bite out of your bread roll. You'll eat exactly the same ingredients but will feel fuller.
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One more important aspect is the shape of your food. Apples might be good for you, but there's a big difference between an apple smoothie, a bag of apple slices and a whole apple, even if they all have the same calories. There more you have to pay attention to eating, the faster your satiety meter rises.
If you can make a great chicken sandwich, it will be even better if you just put everything on a plate and eat it piece by piece: slice off a piece of the grilled chicken breast, dab it into the garlic yoghurt sauce, spear a tomato slice, scoop a bit of shredded lettuce, take a bite out of your bread roll. You'll eat exactly the same ingredients but will feel fuller.
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sparky7536
How to counter hunger in 3 ways:
- Eat protein, protein makes you feel more full for longer, it shuts down your hunger compared to processed food and junk food. Eat 30 to 20 grams of protein with every meal.
- Avoid having any tempting foods in your sight or within reach. Hide it, make it difficult for you to reach.
- Make sure you stay physically active, if you become sedentary your metabolism slows down which accumulates more fat on you and burns less calories. Do exercise, walk around, don't take the lazy way in doing things. Even fidgeting and pacing back and forth keeps your metabolism fast.
That's the gist of the video.
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How to counter hunger in 3 ways:
- Eat protein, protein makes you feel more full for longer, it shuts down your hunger compared to processed food and junk food. Eat 30 to 20 grams of protein with every meal.
- Avoid having any tempting foods in your sight or within reach. Hide it, make it difficult for you to reach.
- Make sure you stay physically active, if you become sedentary your metabolism slows down which accumulates more fat on you and burns less calories. Do exercise, walk around, don't take the lazy way in doing things. Even fidgeting and pacing back and forth keeps your metabolism fast.
That's the gist of the video.
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jeffersonadams8711
I dunno what's going on with my brain, but since I've started exercising vigorously, I have the opposite problem that I was warned about: My appetite has been reduced to such an extent, that I have to _force_ myself to eat my 3rd meal of the day just so I can reach my bare minimum nutritional requirement. This happens even on my aerobic days, where I exercise on the elliptical at 70-80% HRmax for 60 minutes straight. I literally don't think about food anymore, and barely feel hunger at all. And I only started exercising 9 weeks ago (I've lost about 20lbs of fat thus far; went from 155lbs to 135lbs.
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I dunno what's going on with my brain, but since I've started exercising vigorously, I have the opposite problem that I was warned about: My appetite has been reduced to such an extent, that I have to _force_ myself to eat my 3rd meal of the day just so I can reach my bare minimum nutritional requirement. This happens even on my aerobic days, where I exercise on the elliptical at 70-80% HRmax for 60 minutes straight. I literally don't think about food anymore, and barely feel hunger at all. And I only started exercising 9 weeks ago (I've lost about 20lbs of fat thus far; went from 155lbs to 135lbs.
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Wakish0069
When I was 16 I was fat at 168lb, I did the math and found if I ate 600 calories per day I would lose 30lb of fat over the school summer. As a kid I loved burping and remembered that burping would always take away my hunger, so I developed a method I named Burp Breathing - I hold my esophagus open and breathe air directly into my stomach which stretches it out and instantly turns off my hunger. I followed my routine and by the end of summer I had lost exactly 30lb
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When I was 16 I was fat at 168lb, I did the math and found if I ate 600 calories per day I would lose 30lb of fat over the school summer. As a kid I loved burping and remembered that burping would always take away my hunger, so I developed a method I named Burp Breathing - I hold my esophagus open and breathe air directly into my stomach which stretches it out and instantly turns off my hunger. I followed my routine and by the end of summer I had lost exactly 30lb
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GrowingWithDez
I work at a deli, and every night im surrounded by chicken wings, tenders, mozzarella sticks, potato wedges and cookies. I try to fight off craving by packing my heaviest fiber protein meals to eat at work. But I usually cheat by having 1 wing or so, I’ve been cutting for a few momths n been seeing amazing progress now my progress plateaud. I feel my cravings at work is what is slowing it down, anyone has any advice
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I work at a deli, and every night im surrounded by chicken wings, tenders, mozzarella sticks, potato wedges and cookies. I try to fight off craving by packing my heaviest fiber protein meals to eat at work. But I usually cheat by having 1 wing or so, I’ve been cutting for a few momths n been seeing amazing progress now my progress plateaud. I feel my cravings at work is what is slowing it down, anyone has any advice
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GingerWaters
Huh, just as I got meself to around 20% bodyfat, I was given 4 kg of honey from the farmer. Thanks kosmik grandma.
The healthiest possible sugar source. Now I have couple of surplus days, and tomorrow I’ll have full glygogen reserves to have long calorie burning session.
I have to hide them honeys from my hypothalamus, and administrate it in 17g portions, 100kcal at the time.
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Huh, just as I got meself to around 20% bodyfat, I was given 4 kg of honey from the farmer. Thanks kosmik grandma.
The healthiest possible sugar source. Now I have couple of surplus days, and tomorrow I’ll have full glygogen reserves to have long calorie burning session.
I have to hide them honeys from my hypothalamus, and administrate it in 17g portions, 100kcal at the time.
reply
Zantet777u
Hey great vid. Can you make a video focusing on tendons health basically how to avoid those horror shows that you see sometimes where it just snaps like an overly stretched rubber band. I think you’ve tackled key and almost all areas of muscle building and strength gains so hoping this would naturally follow. P. s. a supplements guide being included in the vid would be great too
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Hey great vid. Can you make a video focusing on tendons health basically how to avoid those horror shows that you see sometimes where it just snaps like an overly stretched rubber band. I think you’ve tackled key and almost all areas of muscle building and strength gains so hoping this would naturally follow. P. s. a supplements guide being included in the vid would be great too
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monnoo8221
except that we can think and contrl the hypothalamus, in contrast to the mouse. admitedly, not all can, and thse who can not re slaves of their biological matter.
I made experiments regarding the feeling of satiety, compariing potassium citrate, salt, ground meat, whey shake (40g) and leucine powder in yoghurt with ground almonds. Leucine (4g) was the most effective per gram
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except that we can think and contrl the hypothalamus, in contrast to the mouse. admitedly, not all can, and thse who can not re slaves of their biological matter.
I made experiments regarding the feeling of satiety, compariing potassium citrate, salt, ground meat, whey shake (40g) and leucine powder in yoghurt with ground almonds. Leucine (4g) was the most effective per gram
reply
sonny_jimm
The day after leg day was the absolute worst for me. Hunger through the roof, nothing I ate could satiate me. Now to curb it I've started adding an extra serving of protein for that day, drinking more water to fill my stomach more, bulking out my meals with broccoli and other fibrous foods and chewing sugar free gum throughout the day. The gum really helps me a lot.
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The day after leg day was the absolute worst for me. Hunger through the roof, nothing I ate could satiate me. Now to curb it I've started adding an extra serving of protein for that day, drinking more water to fill my stomach more, bulking out my meals with broccoli and other fibrous foods and chewing sugar free gum throughout the day. The gum really helps me a lot.
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ummahmedca
I dont think youve met a menopausal woman lol
At age 56, my body is not responding like it used to. Staying lean and fit used to be almost effortless. Now, I have to be much more strict with my nutrition and training and still barely see any positive changes. Its bloody frustrating! Im already training 3-5 days/week. Your advice is for the younger generation.
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I dont think youve met a menopausal woman lol
At age 56, my body is not responding like it used to. Staying lean and fit used to be almost effortless. Now, I have to be much more strict with my nutrition and training and still barely see any positive changes. Its bloody frustrating! Im already training 3-5 days/week. Your advice is for the younger generation.
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dirtyunclehubert
isnt it hilarious in face of everything we hoomenz achieved, that we still run around with funny little stone age brains who say WHAT DIET LOSING WEIGHT IS HEALTHY OMG WE GONNA STARVE LETS CARBOLOOOAAAAD
also, dont ignore emotional hunger. thanks to psyllium, i realized - i might be physically satiated, but my brain says you need reward, you need food.
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isnt it hilarious in face of everything we hoomenz achieved, that we still run around with funny little stone age brains who say WHAT DIET LOSING WEIGHT IS HEALTHY OMG WE GONNA STARVE LETS CARBOLOOOAAAAD
also, dont ignore emotional hunger. thanks to psyllium, i realized - i might be physically satiated, but my brain says you need reward, you need food.
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jimmyryan5880
If there is something i really love and wont give up make it an event. I love croissants but i wont keep them in my house, I'll get up early on the weekend, walk to a nice bakery, sit with a coffee and focus on it and maybe go for a bike ride because im already up and about. If you scratch the itch really scratch it. Quality of the experience over quantity.
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If there is something i really love and wont give up make it an event. I love croissants but i wont keep them in my house, I'll get up early on the weekend, walk to a nice bakery, sit with a coffee and focus on it and maybe go for a bike ride because im already up and about. If you scratch the itch really scratch it. Quality of the experience over quantity.
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MonkeyKong38
At some point, you'll lose more muscle than fat if you push it too far.
I lost 130 lbs, and at 175 I was a walking zombie with high body fat that’s called a body fat set point.
The lowest I ever got was 20% body fat at 180 lbs, eating 2, 000 calories a day with lots of steps and weight training, and it still wasn’t sustainable.
Never again.
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At some point, you'll lose more muscle than fat if you push it too far.
I lost 130 lbs, and at 175 I was a walking zombie with high body fat that’s called a body fat set point.
The lowest I ever got was 20% body fat at 180 lbs, eating 2, 000 calories a day with lots of steps and weight training, and it still wasn’t sustainable.
Never again.
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Real28
I'm eating 110-180g of protein and 30-50g of fiber daily and my hunger is still wild.
I'm 6ft, 225. Trying to get down to 190. I started at 320, so Ive come a long way. My lowest was 211 but went back up to 238.
But man, my fat cells have divided so many times, the hunger signaling is CRAZY.
I'll try to work on some of these changes.
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I'm eating 110-180g of protein and 30-50g of fiber daily and my hunger is still wild.
I'm 6ft, 225. Trying to get down to 190. I started at 320, so Ive come a long way. My lowest was 211 but went back up to 238.
But man, my fat cells have divided so many times, the hunger signaling is CRAZY.
I'll try to work on some of these changes.
reply
edwardr1250
500 million years ago the biggest threat was starvation Sorry, but humans were not even a sparkle in the creator's eye 500 million years ago. At most, there is some evidence of humans existing as much as 6-million years ago, but most scientists put the origin of human at between 200-300 thousand years ago.
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500 million years ago the biggest threat was starvation Sorry, but humans were not even a sparkle in the creator's eye 500 million years ago. At most, there is some evidence of humans existing as much as 6-million years ago, but most scientists put the origin of human at between 200-300 thousand years ago.
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