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Protein toxicity and the Neanderthal fat factory (don't call me that)

Protein toxicity and the Neanderthal fat factory (don't call me that)

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Rating: 4.0; Vote: 1
Thank you Helix Sleep for sponsoring! Fourth of July Exclusive Partner Offer is running now for a limited time Visit to get 27% off sitewide Paper on the fat factory:
Date: 2025-07-20

Comments and reviews: 20


AI Summary
Abstract:
This video explores the biological phenomenon of protein poisoning (also known as rabbit starvation) and connects it to a significant new anthropological discovery about Neanderthals. The narrator explains that protein poisoning is a rare but serious condition caused by consuming excessive protein without sufficient fat or carbohydrates, leading to a toxic buildup of nitrogenous waste that the body cannot eliminate. This concept provides the framework for understanding a recent finding at the Neumark-Nord 2 archaeological site in Germany. Researchers uncovered evidence of a large-scale fat rendering operation where Neanderthals, 125, 000 years ago, systematically processed animal bones to extract marrow. The scale of this activity suggests a form of small-scale industry and social organization, indicating that Neanderthals used this process not only to maximize calories but also to avoid protein poisoning. This discovery predates similar evidence from Homo sapiens by 100, 000 years, challenging the traditional view of Neanderthals as primitive and highlighting their sophisticated survival strategies and complex social structures.
Protein Poisoning and the Dawn of Neanderthal Industry
0: 00: 05 Protein Poisoning is Real but Rare: The video introduces protein poisoning, a condition resulting from an all-protein, no-fat/carb diet. While rare today, it's relevant in survival situations and provides context for ancient human behavior.
0: 02: 51 The Nitrogen Problem: Protein is unique among macronutrients because it contains nitrogen. When digested, protein metabolism creates toxic nitrogenous waste like ammonia. The liver and kidneys can only process a limited amount of this waste before it becomes toxic.
0: 05: 57 Historical Context: Rabbit Starvation: The condition is historically known as rabbit starvation because people trying to survive on lean game like wild rabbits would get sick. Despite eating, they would suffer from diarrhea and eventually death due to the lack of fat in their diet, leading to a toxic overload.
0: 06: 33 The Importance of Fat: An experiment with Arctic explorer Vilhjalmur Stefansson demonstrated that an all-meat diet is only sustainable with a significant amount of fat. When his diet was restricted to only lean meat, he became severely ill, but he recovered once fat was reintroduced. Fat provides essential non-protein calories.
0: 12: 18 A Groundbreaking Neanderthal Discovery: A new study from a German archaeological site (Neumark-Nord 2) reveals what is described as a Neanderthal fat factory dating back 125, 000 years.
0: 13: 52 Neanderthal Fat Rendering: Evidence shows Neanderthals were systematically collecting and breaking animal bones to extract and render the marrow fat. They likely boiled the bones, possibly in animal skins or bark containers, to melt the fat, which could then be easily skimmed off and consumed.
0: 16: 04 A Key Survival Strategy: This rendered fat was a crucial source of calories and would have allowed Neanderthals to survive winters on otherwise lean game without succumbing to protein poisoning.
0: 17: 12 Evidence of a Complex Society: The sheer scale of the operationinvolving bones from over 172 large animals in one locationsuggests this was a communal, organized activity, possibly a form of small-scale industry with specialized roles.
0: 18: 01 Rewriting the Timeline of Human Ingenuity: This evidence of sophisticated fat rendering by Neanderthals predates any known evidence of the same practice by Homo sapiens by 100, 000 years, further proving that Neanderthals were not simple primitives but an intelligent and resourceful people with complex social organization.
I used gemini-2. 5-pro| input-price: 1. 25 output-price: 10 max-context-length: 200_000 on rocketrecap dot com to summarize the transcript.
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My take from checking out Dr. Berg, Dr. Berry, etc, needing to pretend I'm dirt poor, and working in an industry that pretty much promises I will have health issues by the time I can pull my pension:
-There are levels of health and fitness, and neither is (necessarily) one and the same, but there are overlaps. A lot of your choices are going to be based on 1) Your means 2) Your goals 3) Other individual considerations (in practice, everyone is slightly different and responds to things differently, adjustment periods notwithstanding. In practice, everything is going to come down to short-term and long-term pros and cons and you weighing cost vs benefit.
Technically, yes, HEALTH-wise, your best bet, GENERALLY speaking, is a diet with virtually no sugars, carbs, processed foods, etc, with healthy fats, protein (mostly animal/similar based, any vegetables/fruits should be cooked/prepared properly to fight anti-nutrient factors) vitamins, and minerals, proper rest, regular exercise, etc. There are some that say that long-term carnivore is detrimental, but the studies aren't conclusive about this (yet) so I'm convinced you can be carnivore or CLOSE TO carnivore and be fine. Same with Keto, both Keto and Carnivore put you in Ketosis if done properly.
In terms of FITNESS/working in a demanding industry/etc. things get more complicated. Add to that finances, age, and individual factors, it gets way more complicated. Working a physically demanding job is way tougher on Carnivore/Keto if you aren't used to it. Like it or not, sugar/carbs don't have more efficient/consistent energy levels, but they tend to have higher energy outputs; this basically means that, yes, you can be HEALTHIER overall with virtually no sugars/carbs, but you depending on the severity of your industry, or, how intense or an athelete you are, you probably aren't going to be able to do as much as someone who has sugars/carbs. A bodybuilder that's natty probably won't be able to do as much as as a bodybuilder on steroids and several supplements. But how healthy is that bodybuilder pushing his body to the absolute limit and taking everything under the sun The rabbit hole goes deeper. What about energy drinks Sure, they give you a good kick in the ass -- especially for night shifts -- but how healthy is that 2 months in when your eye starts twitching
So, I'm not necessarily saying it's HEALTHY or FITNESS only. I'm saying don't get the 2 confused and realize you may not always have much of a real choice. Sure, you can try and be HEALTH saint, try to get the mystical 10 hours of sleep after your 10 to 12 hour shift and 2 hour commute when you woke up at 3 AM or 4 AM for the 17th day in a row (good fcking luck) but then it's going to come down way more to how much you can push yourself without any extra help; at some point, you're probably going to sleep past that alarm, going to injure yourself, going to find you have no focus and/or no energy, or snap at your co-workers at a bad time from lack of sleep.
TL; DR, nothing is perfect. I'd say do what you can HEALTH wise, maybe lean a tiny bit into the FITNESS side, and when push comes to shove, do what you gotta do when it's sink-or-swim time very carefully, because everything is pros and cons and cheques and balances. Know your limits and make some wiggle room for your costs; yes, you want a good career until you've saved up enough/can pull your pension, but what's the point if you get hurt or killed at work because you've run yourself ragged, or you end up with a ruined body before you even reach retirement At what point do you pump the brakes or slow down to stay competitive but stay alive and stay HEALTHY Know your limt, stay within it.

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Ok, had to watch pretty much all the way through, but at least you did mention that all modern research has shown that Neanderthals were not brutes like first believed long ago, not just this new study. The way you phrased things for a LONG time made it sound like you thought this recent paper was some revolutionary trend, but to be clear for everyone, we have known Neanderthals had complex lives just like homo sapiens and weren't dramatically more primative for a long time now. Well, at least for a few decades. The list of discoveries of relatively more advanced culture or technology than had been previously understood is long and has been continually and consistently growing with time.
While interesting for sure, this new study isn't revolutionary or paradigm changing or anything, it's just an additional piece of evidence.
This also should help people understand a little detail that always intrigues people after they think about it, namely, How did our ancestors figure food stuff out without modern science As in, what is poisonous or not, what things need processing to be eaten, etc. The answer is almost as simple as We have had a very, very, very, very, very long time. And these discoveries weren't always made even by anatomically modern humans or even behaviorally modern humans, it goes all the way back to our other hominins in some cases. When you have tens or hundreds of thousands of years available, you don't even need particularly effective experimentation. Pretty much all you need is language and the amount you can achieve over time is. well, as evident, exponential. It took us quite a while to get going, but the exponential nature of accumulating knowledge simply by being able to transmit abstract ideas between people so that we don't just have access to the sum of our own knowledge accumulated through life, and not even just from our family, but rather we have access to an incredibly percentage of the combined knowledge of all humans (and hominins apparently) that have ever lived.

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If there ever were such a people that ate high protein and low fat, something would have to be interfering with their instincts. In modern times, we assemble our meals, piece by piece, sometimes even nutrient by nutrient (we extract sugars, salt, proteins, fats, nutrients, etc, and then we put them back together in unnatural ratios, or eat them uncoupled from nutrients that they always came with in native settings. When living in the wild, you’ll get your nutrients not an extracted form. So when your tribe has brought back, for instance, a bison or a mammoth, you are, by way of preference, able to select tissues that are higher in whatever your body needs most, rather than guess what quantities you need when assembling the dish yourself, and further when you select how much of that food to eat. Fat tastes good, especially to a people who haven’t been told their whole lives that it’s the devil and will kill you and your loved ones, and even more so to a body that has been eating a diet that is very lean (again, by way of circumstance, like winter. I suspect that intentionally avoiding available fat under the above conditions would be a kin to attempting to hold your breath until you pass out. All of that said, there are aberrant cultures that crop up where, for whatever reason, culturally decide that a certain food is bad for you, but I suspect that that requires the odd behaviors of humans living in chiefly man-made environments, where the inputs that they evolved with are likely missing (for instance, we had to invent exercise because the means of our survival no longer provided the health quantity of physical activity, and therefore start acting strangely (i. e, humans living in non-native habitats, in (self)captivity (like today.
I highly recommend the work of Fred Provenza and his study of animals, their diets, and their abilities to select the nutrition that they need.

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Late to the game here, and it took me awhile to realize that this was actually an anti-carnivore tirade.
Protein poisoning can only happen in the absence of an exogenous (the food one is eating) or endogenous (already in the body) energy source; in other words, fat. Protein is not an energy source, although very small amounts of it can be converted to glucose by the liver via the process of neoglucogenesis, and glutamine is used for certain specific cellular energetic processes. You can absolutely eat ENORMOUS amounts of protein, as long as it is accompanied by fat (or, perhaps, carbohydrates, although I don't know if that hypothesis has actually been tested. Competitive eaters eat far more than 2 grams of protein per sitting, and our prehistoric ancestors, who ate sporadically much as other carnivores do, undoubtedly glutted themselves on meat when they made a kill after a long forced fast. Once again, it is what you eat with the protein that mitigates the pathophysiological effects of pure protein, and as long as you have stores of fat in the body you CANNOT suffer from Rabbit Sickness.
Other little corrections to this narrative: Many arctic peoples did not eat algae or berries, simply blubber and meat/fish, and you do not need to eat organ meats to keep from getting scurvy on a carnivore diet.

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Low-key anti-meat propaganda. ; -) But I thought we were over the neanderthals were dumb myths. I also thought that the Eskimo diet had been debunked a few times already. But this is the internet--if it hasn't been covered a couple of dozen times yet, then we probably need another video about it.
Also, it's not a problem that an industry funds studies related to their industry. It's only a problem if they skew or misinterpret the results. Also, private groups unrelated to the industry are also perfectly capable of funding studies, too. So Adam is assuming too much about getting rid of public science. I also don't understand why people think government-funded science is neutral and unbiased. I mean, really The politicians who want to exercise so much control and power over your lives are neutral and unbiased Don't be naive! If you believe that, I've got a lock-box retirement fund to sell you. If I send it to you by USPS, you may get it eventually. Funny how people readily believe in the biases of other people, but not their own biases.

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Fun thing is that carnivorous diet never means eat only meat. It mean eat only animal products. Milk, eggs, organs, like author mentioned liver, fish, mollusks - basically anything which isn't plant or mushrooms. And this diet actually really make sense if done properly. It is expansive as hell in this economy thou. And not only in USA, but all around the world. It is extreme quest to find actually milk cheese in my country and it will cost inadequate amount of money. Thankfully pork meat is relatively easy to buy, which is fatty by default.
Overall there are many things which our ancestors actually done and now it looks like WE NOW actually dumber, which is medicinal fact thou. There was real industry in many places long before we even invent this word. Thinking that our ancestors was dumb is insult for ourself. They KNOW just another knowledge which attrophied in us, because we now don't need to know which grass You actually can eat and when.

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I remember the diet craze using liquid protein where people died. Yet I knew about a dozen women who DID lose a bunch of weight (this was 1999ish) and scrambled to get aa much as they could, stockpiling it as it was taken off the market.
Note: you drag politics into your video, know that other people, who still want science ALSO understand that not everything can be funded. Look at it this way, if the economy is driven full speed until it crashes then NO science will be funded. I'd rather the research be put on a temporary diet so when things are better the research can be picked up again.
I expect this comment will be removed instead of having a conversation and exchange of views because that's what unreasonable people do. If they can't win by logic they go emotional and try to win by cancel the other.

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The ending statements: I point to Milo Rossi's (MiniMinuteMan's) video about the 130, 000 year old mastodon kill, the first hominid in North America, along with a few other ancient graffiti (Half-dan was here, or the Roman graffiti, Roman travel souvenirs, or the ancient pet burials - For as long as humans have been human, we have all been human. And, in some cases/ways Even before that.
Every single person is special and unique but humanity, as a whole, we aren't. Many of the things that are called uniquely human aren't just shared with pre-human hominids, not even just shared among primates, or among mammals: depending on what you look at, it's just life.

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Honestly anyone who's been paying attention to anthropology the last few decades shouldn't be surprised that this fat rendering was happening. Over and over again neanderthals have proven again and again that they were much more advanced than we thought they were and I don't think they are done doing that yet you have to remember that very little of what they did is even possible to be preserved, even the bones and stuff that can be preserved still take a large amount of luck for the right conditions and for us to find.
I'm telling you right now our minds would be blown if we knew everything that they did.

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Adam you didn't give this the rigor of other subjects you've made videos about because, I believe at least, the assumption supported your priors. Protein poisoning isn't an acute toxicity of protein it is a chronic lack of essential fatty acids. It's a nutrient deficiency which is why studies showing 50% protein intake don't result in nitrogen toxicity. There is not a single study showing any human OR animal suffering from protein poisoning under lab conditions unless it was already suffering beforehand. It's a lack of essential fats or the result of some other chronic condition the undergirds the nitrogen cycle.
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They probably used the rendered fat for frying or preserving.
Or maybe they had already discovered how to produce soap.
But surely they didn't ate it straight plain in chunks.
Bone marrow is so delicious when just roasted, or eaten even raw.
Moreover, at that time humans still had many species of megafauna at their disposal and those gigantic animals had plenty of subcutaneus fat which could be used for calories.
Unless. it was during an interstadial warming period (like today) and the animals had somehow lost their subcutaneous fat.

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The reason moderns need so much vitamin C is that our diet is high in carbohydrates. The latter has a very similar molecular structure to C and they compete for the same receptors. Without carbs, our need for C is close to, but not, zero.
A reason offered for the extinction of Neanderthals is that they never invented the bow and arrow. They only had spears and had to get up close and personal with the megafauna. Lots of Neanderthals had broken bones.
The carnivore diet and the Inuit disproves his last statement. No veggies necessary to thrive.

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Neanderthals were in Europe what native americans were in Americas, aboriginals in Australia, maoris in New Zealand etc etc etc - they were people perfectly adapted (over very long time) to living in their environment who got overrun, killed and kicked out from their lands by invading intruders. And those intruders were the same people who after Neanderthals have been doing it everywhere, including to people mentioned earlier. And they are our ancestors, and so it's also in us.
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So Neanderthal boiled bones 100K before homosapien because they had to. Is that a fair conclusion The Neanderthal who didn’t boil bones in those climes didn’t make it.
The industry part is surprising, but if I think about it, I mean to say, it’s cold so cooperate or die. Those who were willing to cooperate lived and had cooperative kids. Isn’t it reasonable to wonder if cooperative industry began for homosapiens in much the same way

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I've seen protein suggestions before, and there's a problem. I weigh 330 lb, and have 38% body fat. Do I count the fat as 'body weight' It would make more sense to use lean body mass, 175 for me. Note that I'll never weigh 175 lb, but does more fat mean more protein in the diet Using a value of 0. 8g/lb that would mean 140g of protein. ChatGPT recently recommended a 200g protein level, but waffled when I tried to find the sources.
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OMG more fallacies. Rabbit starvation occurs when you don't get enough fat. The optimal ratio of fat to protein is a 1: 1 ratio. And I dare anyone to eat too much protein at a 1: 1 ratio of any meat. And if I do get a lean cut of meat, I can only eat so much same as with fatty cuts. In today's society protein poisoning does not exist, so why make a video about it. Also no, vegetables are not a good idea for anyone.
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Personally, I'm just glad that this is absolutely a non-issue for those practicing the Lion diet and the like. You know, since those diets come nowhere close to the protein levels necessary for this condition, and these diets are supplemented with all essential vitamins, minerals, and fiber required for their safe practice.
So anyway, this happened to a person in some weird edge case in the past huh. Cool.

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So, what is it about eating fat (in a protein heavy diet) that prevents the effects of protein poisoning
Is it because without the fat, the body needs to break down protein more for it's energy needs With the fat, the body can essentially ignore digesting the protein and get it's energy from the fat, but without he fat, the body needs to digest protein more, which eventually leads to protein poisoning

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My closest experience to this was when was on a diet with most of my macro intake was lean protein I decided to go for a fasted 100km bike ride & then a 25km fasted run the following day with absolutely nothing like a sensible amount of training beforehand.
I had clearly catabolized a fair amount of muscle doing that & was excreting ammonia in my sweat for about 2-3 days afterwards.

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